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CP 471,474

Product Name
CP 471,474
CAS No.
210755-45-6
Chemical Name
CP 471,474
Synonyms
CP 471,474;PF-1626077;2-(4-(4-Fluorophenoxy)phenylsulfonamido)-N-hydroxy-2-methylpropanamide;2-[[[4-(4-Fluorophenoxy)phenyl]sulfonyl]amino]-N-hydroxy-2-methylpropanamide;Propanamide, 2-[[[4-(4-fluorophenoxy)phenyl]sulfonyl]amino]-N-hydroxy-2-methyl-
CBNumber
CB61389258
Molecular Formula
C16H17FN2O5S
Formula Weight
368.38
MOL File
210755-45-6.mol
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CP 471,474 Property

Melting point:
135-137°C (dec.)
Density 
1.375±0.06 g/cm3(Predicted)
storage temp. 
room temp
solubility 
DMSO: ≥20mg/mL
pka
9.33±0.50(Predicted)
form 
powder
color 
white to off-white
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Safety

Hazard Codes 
Xn
Risk Statements 
22
WGK Germany 
1
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PZ0137
Product name
CP-471474
Purity
≥98% (HPLC)
Packaging
5mg
Price
$130
Updated
2024/03/01
Sigma-Aldrich
Product number
PZ0137
Product name
CP-471474
Purity
≥98% (HPLC)
Packaging
25mg
Price
$404
Updated
2024/03/01
Cayman Chemical
Product number
29442
Product name
CP 471,474
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
29442
Product name
CP 471,474
Packaging
5mg
Price
$86
Updated
2024/03/01
Cayman Chemical
Product number
29442
Product name
CP 471,474
Packaging
10mg
Price
$153
Updated
2024/03/01
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CP 471,474 Chemical Properties,Usage,Production

Description

CP 471,474 is a broad-spectrum inhibitor of matrix metalloproteinases (MMPs) with IC50 values of 0.7, 16, 13, and 0.9 nM for MMP-2, MMP-3, MMP-9, and MMP-13, respectively. It is selective for these MMPs over MMP-1 (IC50 = 1,170 nM). CP 471,474 reduces left ventricular enlargement and decreases the incidence of cardiac rupture in mouse models of myocardial infarction when administered at doses of 120 mg/kg twice per day and 240 mg/kg per day, respectively.

Chemical Properties

White Solid

Uses

A broad spectrum inhibitor of matrix metalloproteinases that attenuates early left ventricular dilation after experimental myocardial infarction in mice. Studies show that it also inhibits cigarette smoke-induced lung inflammation and the progression of emphysema in guinea pig models.

Biochem/physiol Actions

CP-471474 is a broad spectrum inhibitor of matrix metalloproteinases. CP-471474 has a low nM IC50 efficacy for MMP-2, MMP-3, MMP-9, and MMP-13. CP-471474 has low potency against MMP-1 (IC50 > 1 uM). CP-471474 prevents left ventricular remodeling after experimental myocardial infarction in mice. CP-471474 also inhibits cigarette smoke-induced lung inflammation and the progression of emphysema in guinea pig models.

CP 471,474 Preparation Products And Raw materials

Raw materials

Preparation Products

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CP 471,474 Suppliers

Canada 1 China 29 India 1 United Kingdom 1 United States 11 Global 43
AdooQ BioScience, LLC
Tel
+1 (866) 930-6790
Fax
+1 (866) 333-9607
Email
info@adooq.com
Country
United States
ProdList
2784
Advantage
58
EMMX Biotechnology LLC
Tel
888-539-0666
Fax
888-539-0666
Email
info@emmx.com
Country
United States
ProdList
8449
Advantage
60
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
19892
Advantage
58

210755-45-6, CP 471,474Related Search:

4-Fluoro-3-phenoxybenzaldehyde 4-PHENOXYBENZENESULFONYL CHLORIDE 2-Phenoxyethanol

  • PF-1626077
  • CP 471,474
  • 2-[[[4-(4-Fluorophenoxy)phenyl]sulfonyl]amino]-N-hydroxy-2-methylpropanamide
  • 2-(4-(4-Fluorophenoxy)phenylsulfonamido)-N-hydroxy-2-methylpropanamide
  • Propanamide, 2-[[[4-(4-fluorophenoxy)phenyl]sulfonyl]amino]-N-hydroxy-2-methyl-
  • 210755-45-6
  • C16H16FN2O5S
  • Amines
  • Aromatics
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Pfizer Compounds
  • Pharmaceuticals
  • Sulfur & Selenium Compounds
  • Heterocycles